在接受生物治疗的类风湿性关节炎患者的肠球菌性肌肉炎
Dilara Bulut Gökten1, Rıdvan Mercan2
1Department of Rheumatology, Tekirdag Namik Kemal University, 59059, Tekirdag, Turkey. dilarabulutgokten@gmail.com.
Zeitschrift fur Rheumatologie
|January 30, 2026
概括
肠球菌性肌肉炎是一种罕见的骨肌肉感染,发生在患有类风湿性关节炎的免疫功能低下患者身上. 及时诊断和抗生素治疗导致了康复,突出了免疫抑制个体的风险.
科学领域:
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 肌肉炎是一种细菌骨肌肉感染,在全球范围内不常见,但在免疫受损患者中在温带地区增加.
- 金黄色葡萄球菌是常见的原因,而Enterococcus faecalis pyomyositis异常罕见.
- 风湿性关节炎 (RA) 患者接受联合免疫抑制疗法,患机会性感染的风险增加.
研究的目的:
- 报告一种罕见的Enterococcus faecalis pyomyositis病例,该病例发生在接受联合免疫抑制治疗的类风湿性关节炎患者身上.
- 强调免疫功能低下患者罕见感染的诊断挑战和管理.
- 突出结合性免疫抑制剂在发展肌肉炎中的潜在诱导作用.
主要方法:
- 一个62岁的女性类风湿性关节炎患者的案例研究,患有长期的肩部疼痛,胀和全身症状.
- 实验室检查包括全血细胞计和炎症标志物.
- 对比增强磁共振成像 (MRI) 用于部可视化.
- 手术排水和微生物培养.
- 在抗生素治疗期间进行临床和实验室监测.
主要成果:
- 患者出现了与根深蒂固的感染相一致的症状,包括发烧和炎症标志物升高.
- 核磁共振扫描显示,围肌肉中存在一个大型的多部位.
- 来自的培养产生了Enterococcus faecalis.
- 患者在向抗生素治疗后迅速改善了临床和实验室的情况.
结论:
- 这一病例是第二个被记录的风湿性关节炎患者肠球菌性肌肉炎病例.
- 联合免疫抑制疗法 (甲托雷克萨特,阿达利穆马布,皮质类固醇) 可能累积增加对罕见感染的易感性,如肌肉炎.
- 临床医生必须保持对免疫功能低下的患者中肌肉焦点疼痛和全身症状的肌肉炎的高度怀疑,以便及时诊断和治疗.
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