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Updated: Jan 31, 2026

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
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携带GluN2B蛋白质截断变体的小鼠改变了NMDA受体子单元的组成,它们的行为重复了患者的表型

Klevinda Fili1,2, Viktor Kuchtiak1,3, Eni Tomovic1,3

  • 1Institute of Physiology, Czech Academy of Sciences(CAS), Videnska 1083, Prague 4, 142 00, Czech Republic.

Cellular and molecular life sciences : CMLS
|January 30, 2026
PubMed
概括

在GRIN2B中,蛋白质缩减变异会导致哈普隆缺陷,改变NMDA受体功能,并导致小鼠中度神经发育影响. 这项研究揭示了GRIN2B相关智力障碍背后的机制.

关键词:
绿色的基因是绿色的基因.这就是GluN2B.道病变是一种通道病变.葡萄糖酸盐受体的受体是什么转基因小鼠模型的模型.

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