从出生到之后:预测CSF转移在产后MMC关闭中的发生率和时间
Katherine Daniels1, Kelsi M Chesney2, Brannan E O'Neill3
1Princeton University, Princeton, NJ, USA.
概括
骨髓髓瘤结核 (MMC) 患者通常会发展出水头症,需要切换. 在MMC患者中,出生时额头角比 (FOHR) 和水头 (HCP) 的升高预测了分流的需要和时间.
科学领域:
- 儿科神经外科 儿科神经外科
- 脊柱二叉的研究
- 脑水管管理 脑水管管理
背景情况:
- 骨髓瘤结核 (MMC) 与关节依赖性水头症的高发病率有关.
- 常常需要进行心室关节切换 (VPS),但会增加MMC患者的终身发病率.
研究的目的:
- 在MMC患者中确定VPS安置的风险因素.
- 为了确定VPS插入的发生率和时间.
- 改善结果,并为有关MMC中脑水性病的家庭咨询提供信息.
主要方法:
- 对125名接受产后MMC关闭的患者 (1998-2022) 的回顾性审查.
- 分析VPS安置,插入时的年龄,并比较分离和无分离的队列.
- 利用曼-惠特尼U,韦尔奇的t测试,费舍尔的精确测试和尤登的指数来识别水脑 (HCP) 和前额角比 (FOHR) 的预测因素和最佳值.
主要成果:
- 69%的MMC患者需要VPS,其中94%是在出生后2个月内放置的.
- 在出生时更高的FOHR和HCP预测了VPS安置.
- 早期VPS插入的FOHR是一个显著的预测指标 (最佳值>0.48).
结论:
- 出生时FOHR和HCP的升高预示着MMC患者的分流依赖性水脑病.
- 特定的门 (FOHR>0.48,HCP>50%) 可以帮助早期识别和管理.
- 这些发现支持改善家庭咨询和及时干预MMC的水头.
关键词:
头部液体 (Hydrocephalus) 是一种脑水性疾病.骨髓灰质炎是一个巨大的疾病.脊椎异形症是指脊椎异形症的发生.腹腔上腺突变 (Ventriculoperitoneal shunt) 已经开始使用.更多相关视频
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