最近在病理生理学和治疗等离子体细胞失光症方面的进展
1Division of Clinical Oncology/Hematology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo, 105-0003, Japan. kaz-suzuki@jikei.ac.jp.
多发性骨髓瘤的预后随着新的疗法而有所改善,特别是在三级暴露 (TCE) 患者中. 功能性治疗,包括长期控制疾病和抑制最小残留疾病 (MRD),现在是一个现实的目标.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 多发性骨髓瘤是一种无法治愈的血细胞癌症.
- 之前的治疗改善了结果,但对于三级暴露 (TCE) 患者来说并非如此.
研究的目的:
- 审查多发性骨髓瘤治疗方面的进展.
- 通过新疗法突出显示TCE骨髓瘤的改善结果.
- 将功能疗法定义为治疗目标.
主要方法:
- 关于最近临床试验和治疗进展的文献综述.
- 对三重类暴露多发性骨髓瘤治疗结果的分析.
- 定义和探索多发性骨髓瘤的功能治疗方法.
主要成果:
- 卡特-T细胞治疗和双特异性抗体显著改善了TCE髓瘤的预后.
- 功能性治愈,以持续的MRD抑制为特征,是可以实现的.
- 良好的免疫微环境是长期控制疾病的关键.
结论:
- 新型疗法为以前耐火的多发性骨髓瘤提供了新的希望.
- 功能性治疗代表了向长期管理的转变,而不是完全根除.
- 对免疫调节的持续研究对于实现功能治愈至关重要.
更多相关视频
07:37Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
Published on: November 17, 2017
10:03Investigating the Detrimental Effects of Low Pressure Plasma Sterilization on the Survival of Bacillus subtilis Spores Using Live Cell Microscopy
Published on: November 30, 2017
相关概念视频
Pneumonia II: Pathophysiology
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Hypertension II: Pathophysiology
Pathophysiology of Vomiting
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Protein Buffers in Blood Plasma and Cells
Certain amino acids can exist in a zwitterion state at a...
