跨膜模板前列腺活检 (TTPB) 对选择性血清生物标志物的影响:一项临床试点观察性研究
Marcus Dyer1,2,3, Peter Ella-Tongwiis4,5, Nana Yaa Frempomaa Snyper4,5,6
1Maelor Academic Unit of Medical and Surgical Sciences (MAUMSS), Betsi Cadwaladr University Health Board (BCUHB), Wrexham Maelor Hospital, Wrexham, Wales, UK. marcusdyer98@gmail.com.
International urology and nephrology
|January 30, 2026
概括
跨腺模板前列腺活检 (TTPB) 可以改变特定的血清生长因子. 在这项研究中,PDGF-AA和TGF-alpha增加,而EGF和Flt3连接体减少,没有观察到重大并发症.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 生物化学 生物化学
背景情况:
- 前列腺癌的诊断依赖于前列腺活检.
- 跨关前列腺活检 (TTPB) 正在获得吸引力,因为与跨直肠方法相比,感染率较低.
- 有限的数据存在于TTPB后的血清生物标志物变化及其临床相关性.
研究的目的:
- 为了研究经膜模板前列腺活检 (TTPB) 后的血清生物标志物改变.
- 探索这些生物标志物变化与临床结果之间的相关性.
- 评估与TTPB相关的安全性和并发症率.
主要方法:
- 一个观察性的,在组内,重复测量研究设计.
- 从6名TTPB前患者和TTPB后30分钟和240分钟收集的血清样本.
- 使用Luminex®性能测试对13种人类生长因子进行量化,并审查临床结果.
主要成果:
- 在TTPB后的血清PDGF-AA和TGF-alpha度显著增加 (p≤0.05).
- 在TTPB后血清EGF和Flt3连体度显著下降 (p≤0.05).
- 没有报告其他测量生物标志物的显著变化,也没有报告术后并发症.
结论:
- 观察到的血清生物标志物变化 (PDGF-AA,TGF-α,EGF,Flt3连接体) 可能表明TTPB后的炎症或瘤反应.
- 需要对更大的队列进行进一步的研究,以了解生物标志物的作用和与TTPB结果的相关性.
- 开发临床工具的潜力,以预测或识别患有TTPB后并发症风险的患者.
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