相关实验视频

Updated: Jan 31, 2026

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

对CRSsNP患者嗅觉功能障碍风险因素的分析:一个前性病例对照研究

Weiqun Gong¹, Meng Wang¹, Jun Huo¹

¹Department of Otorhinolaryngology, Shanghai Xuhui Center Hospital, China.

Ear, nose, & throat journal

|January 30, 2026

概括

在没有鼻息肉的慢性鼻炎 (CRSsNP) 中,嗅觉功能障碍 (OD) 与鼻腔体积较小和IL-5和IgE等炎症标志物较高有关. 这些因素有助于早期发现OD,以获得更好的治疗.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
鼻科鼻科是指鼻科的专家.
嗅觉科学嗅觉科学

背景情况:

没有鼻的慢性鼻炎 (CRSsNP) 是一种常见的疾病.
嗅觉功能障碍 (OD) 显著影响患者的生活质量.
在CRSsNP中识别OD的风险因素对于管理至关重要.

研究的目的:

在没有鼻息肉的慢性鼻炎 (CRSsNP) 患者中识别嗅觉功能障碍 (OD) 的独立风险因素.
评估OD所识别的因素的预测价值.
为CRSsNP患者的临床管理策略提供信息.

主要方法:

一项前性研究涉及93名受试者,包括有或没有OD的CRSsNP患者,以及健康的对照.
进行了嗅觉测试,CT扫描 (Lund-Mackay),内镜评估 (Lund-Kennedy) 和生化分析 (IL-5,IgE,STOMP).
使用后勤回归和ROC曲线分析来识别风险因素并评估预测价值.

主要成果:

患有OD的患者鼻腔体积和STOMP数量显著降低.
在OD组中观察到升高的隆德-麦凯CT得分,隆德-肯尼迪得分,IL-5和IGE.
鼻腔体积,隆德-麦凯得分,隆德-肯尼迪得分,IL-5,IgE和STOMP被证实是OD的独立预测因素.

结论:

鼻腔体积,CT/内镜评分,IL-5,IgE和STOMP与CRSsNP中的OD显著相关.
这些参数有效地选CRSsNP患者的嗅觉异常.
使用这些因素早期识别OD可以优化临床策略并改善患者的治疗结果.

关键词:

没有鼻的慢性鼻炎.互白素-5-5的作用是什么粘膜嗅觉标记蛋白质阳性细胞计数 (STOMP)鼻腔的体积和鼻腔的体积.嗅觉功能障碍嗅觉功能障碍

更多相关视频

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Published on: March 25, 2021

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

相关概念视频

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...

Relative Risk

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...

Transcription Factors

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...