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Updated: Jan 31, 2026

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对草灰菌的Ipflufenoquin的有效性:基于AlphaFold的结构建模和全基因组转录组分析的见解

Sungyu Choi¹, Doeun Son¹, Hyeong-Rok Jang¹

¹Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju 61186, Republic of Korea.

Journal of agricultural and food chemistry

|January 30, 2026

概括

伊普弗洛芬诺基因有效控制草灰菌,甚至是耐药菌株. 然而,它改变了真菌群体,影响了可持续的疾病管理策略.

科学领域:

植物病理学植物病理学
菌类学菌类学是指菌类学.
农业科学农业科学

背景情况:

由 *Botrytis cinerea* 引起的灰色菌对草生产构成重大威胁.
对现有杀菌剂的真菌耐药性需要开发新的控制剂.

研究的目的:

评估新型二酸盐脱酶 (DHODH) 抑制剂ipflufenoquin对*Botrytis cinerea*和其他草病原体的疗效.
调查伊普芬的作用分子机制及其对真菌群体的影响.

主要方法:

进行了*体外*敏感性测定和现场试验,以评估伊普芬诺昆的疗效.
使用结构建模 (AlphaFold2) 和分子对接来确定ipflufenoquin在DHODH上的结合部位.
进行了RNA测序 (RNA-seq) 分析,以了解对伊普芬诺治疗的转录组反应.

主要成果:

伊普弗洛芬诺对*B. cinerea*具有高的*体外*敏感性,对其他测试的病原体具有广泛的活性.
现场和温室试验证实了ipflufenoquin对灰菌的强有力的控制,包括耐真菌杀菌剂的分离物.
伊普鲁芬诺治疗导致真菌群体的转变,有利于不那么敏感的属,并诱导了真菌的压力反应.

结论:

伊普弗洛芬诺昆是一种强大的杀菌剂,用于控制草灰菌,为抵抗耐药菌株提供了新的选择.
了解伊普诺昆对真菌群落的分子相互作用和影响,对于开发可持续的疾病管理策略至关重要.

关键词:

这是一种DHODH抑制剂.在RNA-seqqq.阿尔法2折2是什么意思灰色的模具是灰色的模具这就是IPFLUFENOQUIN.分子对接的分子对接.草草是一种

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