相关实验视频

Updated: Feb 1, 2026

Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line
11:02

Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line

Published on: February 8, 2022

6.4K

一个整合多尺度in silico建模和实验数据的框架预测了跨细胞类型的CAR-NK细胞细胞毒性

Saeed Ahmad1, Kun Xing2,3, Marcelo S F Pereira2

  • 1Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43205.

Proceedings of the National Academy of Sciences of the United States of America
|January 30, 2026
PubMed
概括

一个新的计算模型通过整合各种受体信号,准确地预测了仿真抗原受体 (CAR) -NK细胞细胞毒性. 该工具有助于理解CAR-NK细胞生物学,并改善癌症治疗方法.

关键词:
这是CAR-NK.细胞毒性 细胞毒性多尺度建模模型的使用.定量流动细胞计量学 定量流动细胞计量这些受体是受体受体.

更多相关视频

A Flow Cytometry-Based Cytotoxicity Assay for the Assessment of Human NK Cell Activity06:08

A Flow Cytometry-Based Cytotoxicity Assay for the Assessment of Human NK Cell Activity

Published on: August 9, 2017

25.1K
Preparation and Use of HIV-1 Infected Primary CD4+ T-Cells as Target Cells in Natural Killer Cell Cytotoxic Assays12:07

Preparation and Use of HIV-1 Infected Primary CD4+ T-Cells as Target Cells in Natural Killer Cell Cytotoxic Assays

Published on: March 14, 2011

26.5K

相关概念视频

Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
8.7K
Correlation of Experimental Data01:23

Correlation of Experimental Data

Dimensional analysis simplifies complex physical problems and guides experimental investigations, but it does not provide complete solutions. It identifies the dimensionless groups that influence a phenomenon, but experimental data is needed to establish the specific relationships and validate theoretical predictions.
For example, a spherical particle moving through a viscous fluid experiences drag. Dimensional analysis shows that the drag force depends on the particle's diameter, velocity,...
486
Data: Types and Distribution01:19

Data: Types and Distribution

In biostatistics, data are the observations collected for analysis. There are two main types: parametric and non-parametric. Parametric data, which include continuous (e.g., weight) and discrete numerical data (e.g., number of tablets), assume a particular distribution pattern, often the normal distribution. Non-parametric data do not adhere to a specific distribution and typically comprise nominal (e.g., gender) and ordinal categorical data (e.g., pain scale ratings).
Distributions in...
1.7K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.5K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.5K
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
5.7K