HRD1通过抑制SNAP29的液体-液体相分离来负面调节自溶酶体的形成

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Updated: Feb 1, 2026

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Wenyan Qu1, Di Chen2, Hongyu Zhao2

  • 1School of Basic Medical Sciences and Biopharmaceutical Research Institute, Anhui Medical University, Hefei 230032, Anhui, P.R. China; Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Anhui Medical University, Hefei 230032, Anhui, P.R. China.

Cell reports
|January 30, 2026
PubMed
概括

E3 泛基因酶 HRD1 通过控制 SNAP29 液态液态相分离 (LLPS) 来负面调节自溶酶体的形成. 缺少HRD1可以通过SNAP29凝聚和SNARE复合组合来增强自和自解酶体生物发生.

关键词:
CP: 细胞生物学 细胞生物学人力资源发展计划1 HRD1在SNAP29中,我们可以使用SNAP29.在SNARE组装组合中.自动解体酶体自动解体酶体液态-液态相隔离方法 液态相隔离方法

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