自2006年以来,在奥地利因托斯卡纳病毒感染而导致的进口无菌性脑膜炎,包括从2023年起的一系列病例
Zsòfia I Szojka1, David M Florian2, Adriana Cabal3
1Institute for Medical Microbiology & Hygiene, Division for Public Health, Austrian Agency for Health and Food Safety, Vienna, Austria; ECDC fellowship Programme, Public Health Microbiology path (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
概括
奥地利的托斯卡纳病毒 (TOSV) 无菌性脑膜炎病例正在增加,自2006年以来已有10例确诊病例. 进口TOSV-AM病例可能会因气候变化和城市化而增加.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 托斯卡纳病毒 (TOSV) 是一种新兴的沙传播病毒,负责脑膜炎和脑炎.
- 在过去的二十年中,在奥地利报告了TOSV相关的无菌性脑膜炎 (TOSV-AM) 的零星病例.
- 邻近地区TOSV流行的增加需要在奥地利进行监测.
研究的目的:
- 从2006年到2023年在奥地利识别和描述TOSV-AM病例.
- 描述奥地利TOSV-AM的临床表现和病毒系.
- 评估进口TOSV-AM病例增加的可能性.
主要方法:
- 对向奥地利国家参考中心 (2006-2018) 报告的TOSV病例的回顾性分析.
- 在前往意大利后,在萨尔茨堡 (2023) 诊断出四例进口TOSV-AM病例的前景报告.
- 通过IgM/IgG血清学证实诊断;部分N基因测序用于血统识别.
主要成果:
- 在2006年至2023年期间,奥地利共确认了10例TOSV-AM病例.
- 六个病例被追溯确定 (平均年龄为43岁),而2023年有四个新病例 (平均年龄为45.5岁).
- 在2023年的一例病例中发现了B系菌株,而之前诊断的病例是A系菌株.
结论:
- 本研究介绍了奥地利TOSV-AM的第一个明确的病例系列.
- 这些发现凸显了奥地利进口TOSV-AM病例的潜在增加.
- 气候变化和城市化很可能是全球TOSV流行的日益增长和奥地利未来潜在增加的驱动因素.
相关概念视频
Cranial and Spinal Meninges
4.0K
The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
4.0K
Protein Import into the Peroxisomes
5.4K
Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
5.4K
ABC Transporters: Importer
3.5K
ATP-binding cassette or ABC transporters are a class of ATP-driven pumps that hydrolyze ATP to move solutes across the membrane. They can be grouped into importers and exporters. While exporters are present in all domains of life, importers exist only in bacteria and some plants.
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
3.5K
Nuclear Localization Signals and Import
7.8K
Proteins targeted to the nucleus carry short stretches of amino acid sequences called the nuclear localization signal or NLS. Classical nuclear localization signals are of two types: monopartite and bipartite NLS. Monopartite classical NLS (cNLS) consists of a single cluster of 4-8 amino acids. Bipartite cNLS consists of two clusters of 2-3 amino acids and a 9-12 residue long proline-rich linker bridging the two clusters. Signal clusters are rich in positively charged amino acids such as...
7.8K
What are Viruses?
128.1K
Overview
128.1K
Resistors In Series
6.4K
A resistor is an ohmic device that limits the flow of charge in a circuit. Most circuits have more than one resistor. If several resistors are connected together and connected to a battery, the current supplied by the battery depends on the equivalent resistance of the circuit. The equivalent resistance of a combination of resistors depends on both their individual values and how they are connected. The simplest combination of resistors is the series combination.
In a series circuit, the...
In a series circuit, the...
6.4K


