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Updated: Feb 1, 2026

16:17
The ITS2 Database
Published on: March 12, 2012
32.3K
概括
与瘤坏死因子α抑制剂 (TNF-Is) 相比,雅努斯激酶抑制剂 (JAK-Is) 显示心血管事件风险增加,特别是女性和老年人的血栓形成.
科学领域:
- 药物监督 药物监督 药物监督
- 心血管安全心血管安全
- 免疫调节药物 免疫调节药物
背景情况:
- 简氏激酶抑制剂 (JAK-Is) 是免疫媒介炎症疾病的新治疗方法.
- 越来越多的人担心JAK-Is的心血管安全性.
- 与瘤坏死因子α抑制剂 (TNF-Is) 的比较对于风险评估至关重要.
研究的目的:
- 为了比较JAK-Is和TNF-Is之间的心血管事件 (CVEs) 风险.
- 确定与JAK-Is相关的特定类型的CVE.
- 分析JAK-I相关的CVE风险的人口差异.
主要方法:
- 使用韩国不良事件报告系统 (KAERS) 数据库 (2015-2020年).
- 分析了JAK-Is (托法西提尼布,巴里西提尼布) 和TNF-Is (阿达利穆马布,埃坦塞普特,戈利穆马布) 的不良事件报告.
- 使用不成比例分析计算CVE的报告概率比率 (ROR).
主要成果:
- 与TNF-Is相比,JAK-Is与CVE的风险更高相关 (ROR:4.90).
- 在JAK-Is (ROR:12.70) 中观察到血栓形成的显著信号.
- 在女性和50岁以上的患者中,JAK-Is的CVE风险增加值得注意.
结论:
- 药监数据表明,JAK-Is与TNF-Is之间存在潜在的心血管风险.
- 特别是JAK-I,显示出血栓形成的风险信号.
- 根据性别和年龄进行风险分层对JAK-I治疗有必要.
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