血BDNF水平,BDNF Val66Met多态性,以及它们与异常REM睡眠行为障碍中异常REM睡眠行为障碍中的表转化相关性
European neurology
|January 30, 2026
概括
较低的血脑源性神经营养因子 (BDNF) 水平与异形眼动睡眠行为障碍 (iRBD) 有关. 较高的BDNF水平预测短期转化为神经退行性疾病,表明其作为预后生物标志物的潜力.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 生物标志物研究 生物标志物研究
背景情况:
- 大脑衍生神经营养因子 (BDNF) 对于多巴胺基神经元的存活至关重要.
- 在帕金森病 (PD) 患者中观察到血清BDNF水平降低.
- 周围BDNF及其Val66Met多态性在预发性PD和转化风险仍未得到充分研究.
研究的目的:
- 为了研究外围BDNF水平和BDNF Val66Met多态性在异形眼动睡眠行为障碍 (iRBD).
- 确定这些因素与iRBD患者的短期疾病转化之间的关联.
主要方法:
- 招募了120名iRBD患者和120名健康对照 (HC).
- 对BDNF Val66Met多态性进行了基因分析.
- 测量了血BDNF水平,并对107名iRBD患者进行了全面的临床随访.
主要成果:
- 与HC相比,iRBD患者的血BDNF水平明显较低 (p = 0.002).
- 在iRBD和HCs之间,BDNF Val66Met载体率没有显著差异.
- 较高的血BDNF水平与短期疾病转换风险增加相关 (HR = 3.418,p = 0.003).
结论:
- 血BDNF与iRBD显著相关.
- 血BDNF可以作为神经退行性疾病发展的预后生物标志物.
- BDNF Val66Met的多态性似乎没有参与iRBD的发病或转化.
相关概念视频
REM Sleep Behavior Disorder
1.7K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
1.7K
Substance Use Disorders Affecting Sleep
449
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
449
Insufficient Sleep and Sleep Deprivation
936
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
936
Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels
599
Renal clearance of a drug is influenced by various factors, including its physicochemical properties and plasma levels. These factors play a significant role in determining how efficiently the kidneys eliminate a drug.
One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...
One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...
599
Stages of Sleep
1.4K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.4K
Understanding Sleep
1.6K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.6K


