在孕期晚期,母亲的缓释饮食优化了小牛骨肌肉中的能量代谢
Thaís Correia Costa1, Diana Carolina Cediel-Devia2, Germán Darío Ramirez-Zamudio3
1Department of Animal Science, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
PloS one
|January 30, 2026
概括
孕期母亲缓释饮食增强了小牛骨肌肉能量代谢. 蛋白质组分析揭示了显著的蛋白质表达差异,影响出生后的中央能量通路和肌肉结构.
科学领域:
- 动物科学动物科学
- 营养生物化学 营养生物化学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 孕期母亲的营养极大地影响后代的发育.
- 了解特定的饮食策略,如缓释对胎儿编程的影响,对于畜牧业生产至关重要.
研究的目的:
- 研究孕期晚期母体缓释 (SRN) 补充对布拉曼小牛的骨肌肉蛋白质组和转录组的影响.
- 为了确定与后代骨肌肉中SRN暴露相关的丰富生物过程.
主要方法:
- 16只怀孕的婆罗门奶牛被分配到控制 (CON) 或SRN饮食中.
- 从45天大的小牛身上采集了肌肉活检.
- 进行了RNA测序 (RNA-seq) 和蛋白质组 (HPLC-MS/MS) 分析.
主要成果:
- 转录组分析显示没有显著差异.
- 蛋白质组分析显示,SRN组中蛋白质表达有显著的变化.
- 丰富的生物过程包括中央能量代谢 (例如,乙-CoA合成,TCA循环),/运输和蛋白质折叠.
结论:
- 母亲SRN补充剂对小牛骨肌肉的产后能量代谢产生积极影响.
- 特定的蛋白质变化表明在子宫内暴露于SRN的后代中改善了ATP代谢,葡萄糖代谢和瘤组织.
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