前肌肉适应于中立位置固定运动的多式成像
Sheiren A Martínez-Méndez1, Berenice Martínez-Gutierrez1,2, Zuriel Casillas-Marquez1,2
1Departamento de Física, Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad de México, México.
PloS one
|January 30, 2026
概括
中性位置的固定会导致显著的肌肉缩,减少体积和强度. 这项研究突出了有害的生理变化,强调需要成像来监测恢复期间的肌肉健康.
科学领域:
- 肌肉生理学和失效缩研究.
- 生物医学工程和临床成像应用.
背景情况:
- 肌肉不使用缩是受伤固定后的常见问题,导致肌肉损失和衰弱.
- 作为标准的临床实践,中立姿势固定的生理效应尚未完全理解.
研究的目的:
- 为了研究中立位置固定对老鼠前肌肉的影响.
- 用先进的成像和功能评估来描述固定肌肉中的结构和生理变化.
主要方法:
- 利用热图,断层图像和超声波成像来评估肌肉变化.
- 进行力量测量和组织学分析 (H&E) 来评估肌肉功能和结构.
- 采用疲劳协议来评估固定后的肌肉耐力.
主要成果:
- 固定导致显著的38%的肌肉体积减少和结缔组织增加.
- 在14天后,观察到比力减少了2倍,动率减少了28%.
- 检测到纤维类型转换和50%的疲劳时间增加,表明肌肉特性发生了变化.
结论:
- 中性位置固定,尽管临床使用,诱导肌肉结构和生理学显著的有害变化.
- 临床成像技术对于在固定和康复期间监测肌肉状态至关重要.
- 这些发现支持需要及时进行干预,以减轻因固定引发的肌肉损伤.
更多相关视频
05:18Collection of Skeletal Muscle Biopsies from the Superior Compartment of Human Musculus Tibialis Anterior for Mechanical Evaluation
Published on: September 27, 2020
7.5K
14:36Evaluation of Muscle Function of the Extensor Digitorum Longus Muscle Ex vivo and Tibialis Anterior Muscle In situ in Mice
Published on: February 9, 2013
43.6K
相关概念视频
01:26Muscles of the Anterior Neck
4.7K
The anterior neck muscles are the group of muscles covering the front part of the neck. These muscles are classified into three subgroups. The first one is the superficial muscles, the most visible muscles in the front of the neck. It includes the platysma and sternocleidomastoid. The second group is the suprahyoid muscles, located above the hyoid bone. This group comprises the digastric, mylohyoid, geniohyoid, and stylohyoid. Lastly, the infrahyoid muscles are found below the hyoid bone and...
4.7K
03:26Acids, Bases and Neutralization Reactions
63.7K
An acid-base reaction is one in which a hydrogen ion, H+, is transferred from one chemical species to another. Such reactions are of central importance to numerous natural and technological processes, ranging from the chemical transformations within cells or lakes and oceans to the industrial-scale production of fertilizers, pharmaceuticals, and other substances essential to the society.
63.7K
01:27Acids, Bases and Neutralization Reactions
9.8K
Acids and bases play several important roles in biology. The pH of a biological system can significantly impact the function of biological molecules, including enzymes, proteins, and nucleic acids. For example, enzymes have optimal pH ranges for their activity, and changes in pH can denature or alter their structure, affecting their function. Acids and bases also play a crucial role in cellular signaling and communication. The pH of the extracellular fluid around cells can influence the...
9.8K
02:32Position-effect Variegation
7.1K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
7.1K
01:31Position and Displacement
25.8K
The position of an object defines its location relative to a convenient frame of reference at any particular time. A frame of reference is an arbitrary set of axes from which the position and motion of an object are described. Earth is often used as a frame of reference, and we often describe the position of an object as it relates to stationary objects on Earth. For example, a rocket launch could be described in terms of the position of the rocket with respect to Earth as a whole. On the other...
25.8K
01:03Serial Position Effect
542
The serial position effect is a cognitive phenomenon where individuals are more likely to recall the first and last items in a list compared to those in the middle. This effect is divided into the primacy effect and the recency effect. The primacy effect is observed when the initial items in a list are remembered better. This occurs because these items are rehearsed more frequently or receive more elaborative processing, allowing them to be encoded into long-term memory more effectively. For...
542