在COVID-19早期出院的扩展性血栓预防:一个回顾性队列研究
Sebastiaan T Van't Hoff1, Gea Helfrich2, Sanne Boerman3
1Department of Pulmonary Medicine, Amphia Hospital, Breda, the Netherlands.
PloS one
|January 30, 2026
概括
在家监测的COVID-19患者中,纳德罗巴林预防没有显著减少静脉血栓事件 (VTE). 这项回顾性研究发现,群体之间的VTE发生率或再入院率没有差异,质疑常规使用预防措施.
科学领域:
- 医学研究 医学研究
- 临床医学 临床医学
- 公共卫生 公共卫生
背景情况:
- 由于资源有限,COVID-19大流行需要家庭监测计划.
- 静脉血栓事件 (VTE) 是COVID-19患者的一个担忧,导致一些医院使用预防措施.
- 实践有所不同,一些医院拒绝预防,预计患者在家中的流动性增加.
研究的目的:
- 为了评估纳德罗巴林预防对接受家庭监测的COVID-19患者的VTE发生的影响.
- 为了比较接受纳德罗巴林和不接受纳德罗巴林的患者之间的VTE病率.
主要方法:
- 追溯队列研究的设计.
- 在家庭监测协议下,从不同的医院参与了两个可比的患者队列.
- 队列之间的关键差异是纳德罗巴林预防的管理.
主要成果:
- 分析了来自两家医院的663名患者,分为平等组.
- 没有观察到从统计学上显著的差异VTE发病后出院.
- 包括由于VTE导致的再录取率在各组之间也是可比的.
结论:
- 该研究没有发现证据表明,纳德罗巴林预防在家中监测的COVID-19患者中减少了VTE.
- 结果与一些试验相反,这些试验表明血栓性预防在出院后有好处.
- 研究结果表明,对于未来的家庭监测计划,需要重新考虑常规的血栓预防.
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