治疗前的综合营养指数预测了新辅助化疗和手术后局部晚期直肠癌的存活率
Zhexue Wang1, Liming Zhao1, Pu Cheng1
1Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
一个新的综合营养指数 (CNI) 预测了接受新辅助化疗或放射治疗 (NCRT) 的局部晚期直肠癌 (LARC) 患者的结果. 较低的CNI得分与较差的生存率相关,突出了其预后价值.
科学领域:
- 在瘤学瘤学.
- 临床营养学 临床营养学
- 手术瘤学手术瘤学
背景情况:
- 营养状况对于治疗耐受性和局部晚期直肠癌 (LARC) 的结果至关重要.
- 个别的营养标志物可能不能完全代表整体的营养储备.
- 术后的新辅助化疗放射治疗 (NCRT) 是标准的LARC治疗方法.
研究的目的:
- 评估LARC患者综合营养指数 (CNI) 的预后价值.
- 评估CNI是否预测NCRT和手术后的生存结果.
- 开发一个预测模型,将CNI与病理因素整合起来.
主要方法:
- 在2014-2019年期间接受治疗的336名LARC患者的回顾性分析.
- 使用BMI,体重百分比,淋巴细胞数量,白蛋白和血红蛋白构建的CNI.
- 使用卡普兰-梅尔和考克斯回归的生存分析;名谱开发.
主要成果:
- 较低的CNI得分与较差的整体存活率和无病存活率显著相关.
- 尽管调整了瘤回归等级和ypN阶段,但CNI独立预测了生存结果.
- 综合CNI,瘤回归等级和ypN阶段的nomogram显示出良好的区分和校准.
结论:
- 预治疗CNI是一种实用的营养复合物,与接受NCRT的LARC患者的预后有关.
- 开发的名图可以改善LARC患者的个性化风险分层.
- CNI提供了宝贵的预后信息,超出了传统的病理阶段.
更多相关视频
12:45Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
Published on: February 12, 2022
03:55Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
相关概念视频
Cancer Survival Analysis
The Roles of Bacteria and Fungi in Plant Nutrition
Assessing Body Temperature - Rectal
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
Parentral Nutrition: Centeral and Peripheral Parental Nutrition
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
Predicting Molecular Geometry
Microbial Nutrition
