针治疗老年轻度至中度抑郁症的疗效:随机对照试验的协议
Qingnan Fu1, Kaihui Xiao2, Jie Zhang1
1Department of Psychosomatic Medicine, Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University, 23 Back Street, Art Museum, Dongcheng District, Beijing, China, 86 13801202917.
JMIR research protocols
|January 30, 2026
概括
这项研究调查了针是否可以帮助老年人抑郁症,当与citalopram hydrobromide结合. 这些发现将指导未来的试验,将针与抗抑郁药物药物整合在一起.
科学领域:
- 老年精神病学是一门精神病学专业.
- 综合医学是一个整体的医学.
- 临床试验 临床试验
背景情况:
- 选择性血清素再吸收抑制剂 (SSRI) 是主要的抗抑郁药,但只有60%的患者对其有反应.
- 针治疗抑郁症或增强SSRI耐受性的有效性证据有限.
- 患有抑郁症的老年人需要有效和耐受良好的治疗选择.
研究的目的:
- 为了评估针与citalopram hydrobromide联合治疗60-80岁个体轻度至中度抑郁症的疗效.
- 评估这种联合治疗对抑郁症症状严重程度和认知功能的影响.
- 为未来的大规模临床试验提供初步数据.
主要方法:
- 一个双臂,并行随机受控试验,涉及132名被诊断患有严重抑郁症的参与者 (60-80岁).
- 一组接受了西塔洛普拉姆化物 (高达20毫克/天) 加上36个针疗程超过12周.
- 对照组仅接受了12周的西塔洛普拉姆胺. 主要结局:第12周17项汉密尔顿抑郁量表的响应率.
主要成果:
- 截至2024年10月17日,参与者招生 (n=132) 和数据收集已经完成.
- 数据分析正在进行中,预计2025年10月初步调查结果将公布.
- 研究结果预计将在2026年公布.
结论:
- 这项试点研究探讨了将针与citalopram hydrobromide结合用于老年抑郁症的可行性和潜在益处.
- 预计结果将为未来多中心试验的设计和样本大小提供信息.
- 这项研究可能会推进老年人抑郁症的非药物治疗策略.
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