一个近红外化喷雾探针用于快速和无洗的手术内神经成像
Lijun Wang1, Yushu Xi1, Pingting Gao1
1MOE Key Laboratory of Smart Drug Delivery, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, School of Pharmacy, Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai 200433, China.
Journal of medicinal chemistry
|January 30, 2026
概括
这项研究引入了N4,一种新的近红外喷雾探针,用于在手术期间快速,无洗的神经可视化. 这一进步通过改善神经映射和减少手术内神经损伤风险,增强了光图像引导手术 (FIGS).
科学领域:
- 生物医学工程 生物医学工程
- 手术创新 在外科创新.
- 光成像技术 光成像
背景情况:
- 术内神经损伤是一个重要的手术并发症.
- 目前用于光图像引导手术 (FIGS) 的神经可视化方法缺乏喷雾兼容性和足够的亮度.
- 需要快速,无洗的神经探针来加强外科手术指导.
研究的目的:
- 开发和评估N4,一个新的近红外化喷雾探针用于手术内神经可视化.
- 评估N4在速度,无洗应用和成像质量方面的性能.
- 为了证明N4在FIGS中的实用性,用于外围神经映射.
主要方法:
- 工程N4作为一个螺旋环探针,在酶激活时变得光 (MBP触发的螺旋开放).
- 在生理条件下评估N4的激活光 (6.3倍增加).
- 在手术模型中局部应用N4作为喷雾来可视化坐骨神经和迷走神经,评估神经与肌肉的对比度和小神经分支的可视化.
主要成果:
- N4提供了快速 (∼10秒),无需洗的外围神经的可视化.
- 达到高神经与肌肉对比度 (高达6.4) 的坐骨神经和迷走神经.
- 成功地可视化了0.12毫米小的神经分支,即使在血液污染的外科领域.
结论:
- N4是一种强大的近红外化喷雾探针,可实现实时FIGS神经映射.
- 这种探测器显著推进了下一代外科成像工具的开发.
- N4为减少手术内神经损伤提供了一个有希望的解决方案.
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