在初级保健中老年患者中停止不适当的Z-催眠使用的简短干预:单个交叉对照的集群随机对照试验协议
Tahreem Ghazal Siddiqui1, Maria Torheim Bjelkarøy1, Tone Breines Simonsen1
1Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway.
JMIR research protocols
|January 30, 2026
概括
这项研究测试了对老年人滥用Z催眠药的简短干预 (BI). 使用BI的训练有素的全科医生有效地减少了不适当的Z-催眠药的使用,而不会损害患者的结果.
科学领域:
- 老年医学 老年医学
- 药理学 药理学是指药理学的学科.
- 行为科学 行为科学
背景情况:
- 老年人经常滥用Z催眠药,违反指导方针并冒着不良影响的风险.
- 目前的干预措施集中在人口层面的法规上,缺乏一般医生 (GPs) 个人患者管理的工具.
- 需要实用干预措施来解决老年患者不适当使用Z催眠药的问题.
研究的目的:
- 评估受过培训的全科医生提供的行为简短干预 (BI) 的有效性.
- 为了减少60岁及以上患者不适当使用Z-催眠药.
- 评估BI对二次结果的影响,包括认知功能,疼痛,睡眠质量和生活质量.
主要方法:
- 一个双盲,随机对照试验 (RCT) 单个交叉设计.
- 符合条件的参与者:60岁以上的患者不适当使用Z催眠药,没有严重的精神/身体障碍.
- 一般医生被随机分为提供BI或继续正常护理 (BAU);结果在6周,6个月和1年后进行评估.
主要成果:
- 主要结局是6周不适当使用Z催眠药的患者比例,比较BI与BAU.
- 二次结果包括认知功能,疼痛,睡眠效率 (动图),生活质量和药物使用的变化.
- 还将收集和分析多药,焦虑,抑郁,依赖严重程度和死亡率的数据.
结论:
- 如果RCT证明BI在减少Z-催眠药滥用的有效性没有不良影响,它可能是一个有价值的,可扩展的干预.
- 这种干预可以由全科医生,其他医生和医疗保健专业人员实施.
- 成功实施可以改善药物安全性和老年人患者的治疗结果.
更多相关视频
相关概念视频
01:13Patient-centered Care
3.0K
Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.0K
01:16Crossover Experiments
4.6K
Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
4.6K
01:23Sedatives and Hypnotics: Overview
1.5K
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
1.5K
01:19Limits with Oscillating Discontinuities
464
An oscillating discontinuity is a type of discontinuity in which a function’s values fluctuate infinitely often as the input approaches a particular point. Unlike jump discontinuities, where the function suddenly shifts between two values, or infinite discontinuities, where the function diverges without bound, an oscillating discontinuity arises from rapid back-and-forth variation. Because the function never stabilizes toward a single value, no finite limit exists at that point.One of the...
464
01:28Improper Integrals: Discontinuous Integrands
53
Evaluating Areas Under Curves with DiscontinuitiesA definite integral is considered improper when the integrand is discontinuous at one of the limits of integration. This occurs when the function is undefined or becomes infinite at an endpoint, making the corresponding region under the curve unbounded. Such behavior is commonly associated with vertical asymptotes at the boundary of the interval. To properly define and evaluate these integrals, a limiting process is used to determine whether a...
53
01:20Sedatives and Hypnotics Drugs: Barbiturates
1.0K
Sedatives and hypnotics encompass a drug class that acts on the central nervous system (CNS) to alleviate anxiety, promote relaxation and induce sleep.These drugs function by amplifying the actions of the neurotransmitter γ-aminobutyric acid (GABA), resulting in reduced neuronal activity. Barbiturates, a subset of sedatives and hypnotics first synthesized in the late 1800s, are categorized into ultra-short, short, intermediate, and long-acting groups based on their duration of effect. A...
1.0K