纳米库尔库明可以减轻缺氧后肢无负荷小鼠的肌肉损伤
Rizwan Qaisar1, Saeed Ahmad Khan2, Mutasem Rawas-Qalaji3
1Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, 27272, United Arab Emirates; Space Medicine Research Group, Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates; Cardiovascular Research Group, Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates.
黄素纳米颗粒有效地对抗肌肉损失和细胞压力在小鼠经历后肢卸载和缺氧. 这种新的配方对治疗与不使用和低氧相关的肌肉消耗疾病充满希望.
科学领域:
- 生物医学科学 生物医学科学
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨肌肉缩由缺氧加剧,这是一种与长期不活动和心肺问题相关的条件.
- 黄素在治疗肌肉衰竭方面显示出有前途的治疗作用,但其生物可用性较差.
- 开发了Zin-casein纳米颗粒 (Cur Z-CS NP) 来增强黄素的输送.
研究的目的:
- 评估Cur Z-CS NP在预防在低氧条件下进行后肢卸载 (HU) 的小鼠肌肉恶化方面的疗效.
- 评估Cur Z-CS NP对肌肉功能,组织学和细胞压力标志物的影响.
主要方法:
- 在Cur Z-CS NP中进行了合成和表征.
- 雄性C57BL/6J小鼠在正常和缺氧条件下接受后肢卸载 (HU).
- 小鼠接受了安慰剂,自由黄素或Cur Z-CS NP; 分析了肌肉功能,组织学和基因表达.
主要成果:
- Cur Z-CS NP治疗逆转了HU和缺氧诱导的身体/肌肉体重,握力和肌肉纤维大小的减少.
- 核细胞数量得到保留,而细胞亡,ER压力和亡标志物被Cur Z-CS NP减少.
- 在HU低毒小鼠中,Cur Z-CS NP部分恢复了Myonuclear域 (MND) 大小.
结论:
- 在未使用和缺氧的小鼠模型中,Cur Z-CS NP有效地减轻肌肉缩和细胞应激.
- 这种纳米粒子配方为肌肉消耗条件提供了一个有前途的治疗策略.
- 对Cur Z-CS NP的进一步研究可能会导致对萨科佩尼亚和缓冲症的治疗.
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