患有恶性固体瘤的老年患者静脉血栓栓塞的危险因素:系统性审查
1Department of Biotherapy Research, West China Hospital, Sichuan University, Chengdu 610041, China; West China School of Nursing, Sichuan University, Chengdu 610041, China.
Journal of geriatric oncology
|January 30, 2026
概括
患有癌症的老年人面临着静脉血栓栓塞 (VTE) 的多重风险. 识别这些因素是预防这种脆弱人群中VTE的关键.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 老年病的医生 老年病的医生
背景情况:
- 静脉血栓栓塞 (VTE) 是患有恶性固体瘤的老年患者的一个重大问题.
- 了解VTE风险因素对于制定针对性预防策略至关重要.
研究的目的:
- 系统地分析60岁及以上,被诊断患有恶性固体瘤的患者VTE相关的风险因素.
- 确定有助于VTE发展的关键决定因素,以改善患者管理.
主要方法:
- 在主要数据库 (Ovid MEDLINE,EMBASE,SCIE,SCOPUS) 进行了全面的文献搜索,截至2024年4月.
- 包括的研究使用纽卡斯尔-太华尺度进行质量评估,数据提取由两名独立审稿人进行.
主要成果:
- 涵盖964,290名患者的16项研究确定了29个不同的VTE风险因素,涉及治疗,疾病,并发症,社会人口统计和实验室领域.
- 化疗,晚期瘤阶段,心血管疾病,先前的VTE史 (最强的预测因素),黑人种族和升高的D-二次数水平是显著的风险因素.
- 发现了一个"年龄悖论",非常老年人 (≥85岁) 的VTE发病率下降,可能是由于死亡率竞争.
结论:
- 老年癌症患者的VTE风险复杂,受到多种因素的影响.
- 现有的风险评估模型不足,需要改进.
- 未来的工具应该整合瘤特异性,治疗效果,老年因素和出血风险,以进行个性化静脉突发炎预防.
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