赞坦稳定可可黄乳液:α-曼戈斯的特征,分子相互作用,物理化学稳定性和生物可访问性
Naymul Karim1, Ke Zhang1, Mohammad Rezaul Islam Shishir1
1School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Rd., 212013 Zhenjiang, Jiangsu, China.
Food chemistry
|January 30, 2026
概括
稳定了可可黄乳液与香丹 (XG) 有效封装α-曼戈斯 (αM),提高其稳定性和控制其释放. 这种配方对在胃肠道中输送疏水生物活性物有前途.
科学领域:
- 食品科学与技术 食品科学与技术
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 阿尔法-曼戈斯 (αM) 是一种难以溶解的香,具有潜在的健康益处.
- 提高像αM这样的疏水生物活性物质的稳定性和受控的输送对于它们的治疗应用至关重要.
- 传统配方往往与这种化合物的可溶性和稳定性不佳作斗争.
研究的目的:
- 开发和特征可可黄乳液稳定由香甘 (XG) 用于封装αM.
- 评估XG度对乳液性质,稳定性和αM递送的影响.
- 为了评估这些乳液在模拟胃肠道消化过程中的性能.
主要方法:
- 在不同XG度 (0-0.5%) 的可可黄乳液中封装αM.
- 乳液性质的表征:滴滴大小,多分散度指数,泽塔电位和粘度.
- 评估21天内的物理,化学和微生物稳定性.
- 使用FTIR和XRD进行结构分析.
- 微镜技术 (CLSM,FESEM) 用于滴滴形态学.
- 模拟胃肠道消化研究,以评估生物可访问性和抗氧化剂保留.
主要成果:
- 实现了高封装效率 (77-85%) 和亚微米滴滴大小 (440-540 nm).
- 增加XG度提高了粘度,剪切稀释行为和热/离心稳定性.
- 乳液在21天内表现出极好的稳定性,没有降解.
- 结构分析证实了半晶体矩阵内的αM封装成功.
- 模拟消化显示了XG依赖的控制滴滴行为,αM生物可访问性和抗氧化剂保留.
结论:
- 克桑稳定可可黄乳液是有效提高αM的稳定性.
- 这些乳液提供了受控释放和改善了疏水生物活性的生物可访问性.
- 该配方为胃肠道中疏水化合物提供了一个有前途的输送系统.
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