多中心扩散大B细胞淋巴瘤与长期参与在一个托儿所小猪
Fernanda F Perosa1, Jean C O Menegatt1, Anderson H Gris2
1Setor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9090, Porto Alegre, 91540-000, Rio Grande do Sul, Brazil.
Journal of comparative pathology
|January 30, 2026
概括
本病例报告详细介绍了小猪的一种罕见的多中心淋巴瘤,其特征是B细胞起源和异常的持续参与影响大脑和脊髓,导致.
科学领域:
- 兽医病理学 兽医病理学
- 在瘤学瘤学.
- 猪医学 猪医学 猪医学
背景情况:
- 淋巴瘤是猪中常见的一种瘤,主要影响B细胞,经常出现在淋巴结,脏,肝脏和脏中.
- 多中心淋巴瘤通常涉及这些器官,但很少记录持续性 (脑膜) 参与.
研究的目的:
- 报告一个独特的多中心淋巴瘤病例在一个年轻的小猪.
- 描述这种特定淋巴瘤亚型的临床表现,病理发现和免疫组织化学特征.
- 为了突出第一个记录的同步持续参与的例子,在一个有多中心淋巴瘤的家猪.
主要方法:
- 尸体解剖和细致的组织学检查受影响的组织.
- 免疫组织化学验证B细胞谱系 (CD20+) 并排除T细胞起源 (CD3-).
主要成果:
- 一只70天大的小猪因瘤淋巴细胞的长期和脑膜透而出现后肢.
- 组织病理学证实了大脑和脊髓脑膜块的结节加厚,以及对脊椎节腺的参与.
- 新生细胞透到多个器官,包括淋巴结,脏,肝脏和脏,与多中心淋巴瘤一致.
- 免疫组织化学证实了瘤淋巴细胞 (CD20+) 的B细胞起源.
结论:
- 这是国内猪中首次报告的多中心淋巴瘤病例,同时存在持续性感染.
- 这些发现扩大了对猪淋巴瘤呈现和传播的理解.
- 这一案例凸显了彻底诊断猪中可能与瘤相关的神经症状的重要意义.
相关概念视频
Diffusion
218.5K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
218.5K
Diffusion
6.4K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
6.4K
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion
31.3K
Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
31.3K
Facilitated Diffusion
1.3K
The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
1.3K
Antigens Involved in Adaptive Immunity
1.5K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
1.5K
Protein Diffusion in the Membrane
5.6K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
5.6K


