在雄性大鼠中确定由环境相关的PFAS混合物诱导的认知功能障碍的潜在机制
Bing Li1, Yinan Xu2, Xueyan Guo3
1Shanxi Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Toxicology of Ministry of Public Security, School of Forensic Medicine, Shanxi Medical University, Jinzhong 030600, PR China; Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, PR China.
Environment international
|January 30, 2026
概括
暴露于和多基物质 (PFAS) 会损害雄性大鼠的空间学习和记忆. 这些认知缺陷与神经炎症,神经元损伤和肠-大脑轴中断有关.
科学领域:
- 环境毒理学环境毒理学
- 神经科学是一个神经科学.
- 分子生物学分子生物学
背景情况:
- 和多醇基物质 (PFAS) 是持久性有机污染物,其神经毒性作用尚不完全理解.
- 评估环境相关的PFAS混合物对认知功能的影响至关重要.
研究的目的:
- 研究八种PFAS混合物对雄性大鼠模型中的空间学习和记忆的影响.
- 阐明PFAS诱导的神经毒性的潜在分子机制.
主要方法:
- 雄性大鼠通过口腔 gavage 暴露在 PFAS 混合物 (0-7.000 mg/kg) 中,持续了 28 天.
- 用对象位置识别和莫里斯水迷宫测试来评估认知功能.
- 通过分子生物学试验,外体转录组学和等离子体代谢学来探索分子机制.
主要成果:
- 暴露于PFAS降低了对象位置识别,空间学习和记忆.
- 损伤与神经递质失调,炎症,神经元损伤和肠道屏障受损有关.
- 外体miRNA和血代谢物被确定为PFAS神经毒性的生物标志物.
- PFAS改变了肠道微生物的多样性,影响了微生物群-肠道-大脑轴.
结论:
- 环境相关的PFAS混合物诱导神经毒性,影响认知功能和空间记忆.
- 微生物群-肠-大脑轴在PFAS诱导的神经毒性影响中发挥着重要作用.
- 调查结果强调需要对PFAS暴露的综合风险评估.
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