用于治疗心脏功能障碍的shengmaiyin口服液的化学分析和多维药理学分析
Lifeng Zhao1, Siyang Wu2, Xin Yu2
1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Street, Dongzhimen Nei, Dongcheng District, Beijing 100700, China; Department of Pharmacy, CangZhou Medical College, No. 39, Jiuhe West Road, Yunhe District, Cangzhou, Hebei 061001, China.
Journal of pharmaceutical and biomedical analysis
|January 30, 2026
概括
梅因口服液 (SMY) 含有治疗心脏功能障碍 (CD) 的关键类和类素. 这项研究确定了这些生物活性物质,在CD模型中揭示了它们的复杂相互作用和药物动力学概况.
科学领域:
- 综合医学是一个整体的医学.
- 药理学 药理学是指药理学的学科.
- 分析化学 分析化学
背景情况:
- 梅口服液 (SMY) 是一种传统的中医药,用于治疗心脏功能障碍 (CD).
- 在治疗CD时,SMY的化学成分和药理机制尚未完全理解.
研究的目的:
- 用先进的分析技术来描述SMY的生物活性成分.
- 在CD.的背景下研究这些成分的in silico药理学和in vivo药理动力学.
- 为SMY治疗心脏功能障碍的疗效提供机制性见解.
主要方法:
- 超高性能液态染色学-四极飞行时间质谱学 (UPLC-Q-TOF-MS/MS) 用于化合物识别.
- 网络药理学和分子对接用于in silico药理学.
- 药理动力学 (PK) 分析,包括全球药理动力学寻找 (GPS) 盒分析,在CD模型小鼠中.
主要成果:
- 在SMY中鉴定出132种化合物,在小鼠血中检测出31种;在CD治疗中鉴定出21种关键生物活性物质 (12种林格南,9种沙波宁).
- 网络药理学揭示了这些生物活性物与CD相关蛋白质的多目标相互作用.
- 基因基因分析显示出明显的模式,CD小鼠的心脏具有显著的组织分布和时间依赖的变化.
结论:
- 这项研究阐明了SMY关键成分在治疗心脏功能障碍中的化学基础和药理特征.
- 这些发现突出了SMY中类和类的潜力,用于民族药理学中的精密医学方法.
- GPS盒子分析为多维PK研究提供了一个创新的平台.
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