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Updated: Feb 1, 2026

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肝细胞中UFMylation缺乏会激活KEAP1-NRF2通路,并有助于肝癌发生

Qian Liang1, Shiwen Xu1, Yaoyao Fang1

  • 1Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, Key Laboratory of Aging and Cancer Biology of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, China.

Redox biology
|January 30, 2026
PubMed
概括

通过破坏KEAP1-NRF2通路,UFMylation缺乏会促进肝癌的发生. 这项研究揭示了UFL1调节KEAP1的稳定性,影响肝细胞癌的发展,并提供新的治疗点.

关键词:
肝细胞癌是肝细胞癌.肝细胞 肝细胞 肝细胞通过KEAP1-NRF2路径.在UFL1中,UFL1是UFL1.在UFMylation中进行化.

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