长期的颗粒物暴露和加速的呼吸道恶性转变:从初始损伤到肺癌的多状态轨迹
Jingyi Zhao1, Lequn Zhang1, Na Chen1
1Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China; National Institute of Health Data Science of China, Shandong University, Jinan 250012, China.
Journal of hazardous materials
|January 30, 2026
概括
长期暴露于细颗粒物 (PM2.5) 显著增加患非癌性肺部疾病和进展为肺癌的风险. 这种空气污染还增加了死亡风险,突出了污染控制和早期查的必要性.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 暴露于颗粒物 (PM) 是肺部疾病和癌症的已知风险因素.
- 长期暴露于颗粒物和呼吸道恶性转变之间的确切联系需要进一步调查.
研究的目的:
- 量化长期细颗粒物 (PM2.5) 暴露与呼吸系统疾病进展,包括肺癌发病率和死亡率之间的关联.
- 探索PM相关的呼吸道健康风险中的人口差异.
主要方法:
- 利用7年全国2700万中国成年人的队列.
- 采用加权的多州模型来追踪从基线到肺癌和死亡率的疾病进展.
- 分析了PM2.5和PM10度对过渡风险的影响.
主要成果:
- 每增加10μg/m3的PM2.5与转变为非癌性肺病的风险增加3.4%,转变为肺癌的风险增加4.9%,诊断后死亡风险增加21.1%.
- 暴露于PM2.5也增加了直接死亡风险9.7% (基线至死亡) 和13.96% (非癌症肺部疾病至死亡).
- 女性和城市居民更容易患PM引起的非癌性肺病,而男性和农村人口面临更高的PM相关死亡风险.
结论:
- 长期暴露于PM2.5显著增加了呼吸道疾病进展,肺癌和死亡率的风险.
- 人口统计学因素,如性别和居住地,影响了对PM相关呼吸道疾病的易感性.
- 包括污染控制,早期查和幸存者护理在内的综合战略对于减轻PM对呼吸系统健康的影响至关重要.
相关概念视频
Orthogonal Trajectories
60
Orthogonal trajectories describe the geometric relationship between two families of curves that intersect each other at right angles. One illustrative case involves a family of parabolas that open sideways along the x-axis. These curves share a common shape but differ by a scaling parameter, resulting in a set of curves that all pass through the origin and widen at different rates.Determining Orthogonal TrajectoriesTo identify the orthogonal trajectories for these parabolas, the first step...
60
Classifying Matter by State
103.3K
Chemistry is the study of matter and the changes it undergoes. Matter is anything that has mass and occupies space. Matter is all around us; the air, water, soil, mountains, even our bodies are all examples of matter. Matter is divided into three states — solid, liquid, and gas — that are commonly found on earth. The fourth state of matter, plasma, occurs naturally in the interiors of stars.
103.3K
Lung Capacity
56.3K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.3K
Classifying Matter by Composition
90.4K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
90.4K
Initiation of Translation
39.0K
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
39.0K
Physical and Chemical Properties of Matter
166.3K
The characteristics that enable us to distinguish one substance from another are called properties.
166.3K


