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Updated: Feb 1, 2026

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集成的奥米克和机器学习揭示了环境毒素6PPD-Q诱导的非阻塞性亚子精的分子基础

Xiya Jiang1, Hedong Lu1, Ge Ou1

  • 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230001,China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No. 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Provincial Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, No. 81 Meishan Road, Hefei, Anhui 230032, China.

Ecotoxicology and environmental safety
|January 30, 2026
PubMed
概括

一种轮胎污染物N-(1,3-dimethylbutyl) -N'-phenyl-p-phenylenediamine-quinone (6PPD-Q) 与男性不孕症有关. 这项研究确定了6PPD-Q作为单细胞塞尔托利综合征 (SCOS) 的潜在原因,它通过向像雄激素受体 (AR) 和caspase-8 (CASP8) 等关键基因.

关键词:
6PPD-QQ 是一个机器学习是机器学习.分子对接是分子对接.网络毒理学 网络毒理学只有塞尔托利细胞综合征.

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