在儿科中停止抗药物治疗:现实世界的见解
Deniz Menderes1, Salih Akbaş2, Esra Serdaroğlu3
1Department of Pediatric Neurology, Ankara Etlik City Hospital, Ankara, Türkiye.
Epilepsy research
|January 30, 2026
概括
儿童中断抗发作药物治疗通常是由于持续的发作或精神病学副作用造成的. 诸如 levetiracetam 和 carbamazepine 等特定药物表现出明显的不良事件模式,需要个性化治疗.
科学领域:
- 儿科神经学 儿科神经学
- 症管理 症管理
- 药物监督 药物监督 药物监督
背景情况:
- 抗发作药物 (ASM) 对于治疗儿科至关重要.
- 了解ASM停药的原因对于优化治疗结果至关重要.
- 药物特定的不良事件概况会影响治疗选择和坚持治疗.
研究的目的:
- 确定导致儿童患者停止抗发作药物的关键因素.
- 描述与单疗法和多疗法方案相关的药物特异性不良事件模式.
主要方法:
- 从单一诊所 (2015年1月至2024年9月) 进行小儿患者 (<18岁) 的回顾性分析.
- 数据收集包括人口统计,类型,ASM治疗方案,治疗持续时间和停止治疗的原因 (不充分的疗效或不良影响).
主要成果:
- 在4% (169/4578) 的儿科患者中发生ASM中止,多疗法 (5%) 与单疗法 (3%) 的更高率.
- 停药的主要原因是持续的发作 (28%) 和精神疾病不良反应 (24%).
- 莱维他与精神问题有关 (74%),而卡巴马西平与持续的尖峰和波浪在睡眠期间 (CSWS) 类似的模式 (67%).
结论:
- 持续的发作和精神病的不良影响是导致儿童中断ASM的主要原因.
- 特定的药物-ASM相关性 (莱维他-精神病,卡巴马西平-CSWS类EEG) 强调需要个性化的ASM选择.
- 密切的临床和脑电图监测在儿科管理中至关重要.
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