合成的抗裂变TREM2增强了巨细胞的效细胞化,用于治疗炎症性疾病

Xianghui Dong1, Xiaotian Zhao1, Jinxin Gao1

  • 1Shandong Key Laboratory of Targeted Drug Delivery and Advanced Pharmaceutics, NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012, China.

Cell reports. Medicine
|January 30, 2026
PubMed
概括

研究人员开发了一种抗裂变的TREM2 (CRT) 来增强巨细胞细胞分裂. 这促进了亡细胞的清除,并减少了代谢功能障碍和动脉样硬化模型中的炎症.

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