在肺动脉高血压中3D回声导出右心室主表面应变
Hannah Takahashi Oakland1, Lavanya Bellumkonda2, Lissa Sugeng2
1Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, GA.
3D回声心图的最大主表面应变 (PSMax) 与传统的2D方法相比,在肺动脉高血压 (PAH) 中更好地评估右心室 (RV) 功能,有助于识别右心力衰竭和预测结果.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 肺部病理学 肺部病理学
背景情况:
- 传统的回声心脏学指标,如TAPSE和2D菌株,主要评估纵向RV缩功能.
- 这些常规方法无法完全捕捉右心室复杂的3D变形.
- 目前对右心室 (RV) 功能进行回声心脏学评估存在局限性,特别是在肺动脉高血压 (PAH) 中.
研究的目的:
- 评估3D心声回声学衍生的RV表面变形指标在PAH患者中的实用性.
- 为了比较最大主表面应变 (PSMax) 和它的角度 (ΘMax) 与传统的2D RV函数描述器的有效性.
- 评估PSMax在预测PAH患者30天结果中的预后价值.
主要方法:
- 在右心脏导管术 (RHC) 期间同时获得3D回声心脏图 (3DE).
- 确定最大主表面应变 (PSMax) 和其RV表面变形的角度 (ΘMax).
- 将37名PAH患者 (11名右心力衰竭患者) 与22名对照人进行比较,分析PSMax, ΘMax和30天的结果.
主要成果:
- 在对照组和PAH患者之间,以及在右心力衰竭和无右心力衰竭的PAH患者之间,PSMax显著差异化.
- 在患有右心力衰竭和更差的NYHA功能类型的PAH患者中,ThMax的方向在纵向上转移.
- PSMax证明了预后价值,预测30天结果的截止值为-21.4% (HR 6.8,p=0.022).
结论:
- 来自3DE的PSMax是PAH中右心力衰竭的强有力的标志物.
- PSMax提供了超越传统2D RV功能参数的预后信息.
- 渐进的纵向变形 (ΘMax) 与降低RV功能和PAH中的功能类相关.
更多相关视频
07:02A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
Published on: July 15, 2021
09:22Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
Published on: November 4, 2015
相关概念视频
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
