在接受抗风湿治疗的类风湿性关节炎患者的骨矿物质密度:系统性审查
Owen Taylor-Williams1, Ross Godwin2, Reece Carvallio3
1University of Western Australia, Perth, Western Australia, Australia; Royal Perth Hospital, Perth, Western Australia, Australia; Joondalup Health Campus, Perth, Western Australia, Australia.
Bone
|January 30, 2026
概括
类风湿性关节炎患者可能会从疾病修饰性抗风湿药物 (DMARDs) 中看到骨矿物质密度的好处. 传统的合成 (cs) DMARD显示出希望,而生物 (b) 和有针对性的合成 (ts) DMARD可能会对骨健康产生更大的影响.
科学领域:
- 类风湿病学 类风湿病学
- 整形外科 整形外科 整形外科
- 药理学 药理学是指药理学的学科.
背景情况:
- 风湿性关节炎 (RA) 显著增加骨折的风险,由于系统性骨质损失.
- 疾病修饰性抗风湿药物 (DMARDs) 改善了RA控制,但它们对骨矿物质密度 (BMD) 的影响仍在争论中.
- 了解DMARDs对骨损伤的影响对于管理RA患者骨折风险至关重要.
研究的目的:
- 系统地审查传统合成 (cs),生物 (b) 和有针对性的合成 (ts) DMARDs对 RA 患者的骨质瘤的影响.
- 分析葡萄糖皮质类固醇使用,抗骨质疏松症治疗和疾病活动等因素如何影响DMARD在BMD上的疗效.
- 为了确定特定的csDMARD,bDMARD和tsDMARD药物的骨质疏松效应的潜在差异.
主要方法:
- 一个对13,340条记录的系统审查,其中46项研究符合纳入标准.
- 根据使用的DMARD类型 (csDMARD,bDMARD,tsDMARD) 分析了这些研究.
- 在分析中考虑了同时使用葡萄糖皮质类固醇 (GCS),抗骨质疏松性疗法 (AOT) 和疾病活性水平.
主要成果:
- 传统的合成DMARDs (csDMARDs) 似乎对BMD有益.
- 根据证据平衡,生物DMARDs (bDMARDs) 和有针对性的合成DMARDs (tsDMARDs) 与csDMARDs相比,对骨有更大的积极影响.
- 初步数据表明,不同csDMARD,bDMARD和tsDMARD药物之间的骨质疏松效应存在差异,需要进一步调查.
结论:
- csDMARDs在RA患者的骨质疏松症上表现出积极的影响.
- bDMARDs和tsDMARDs通常比csDMARDs对BMD表现出更明显的积极影响.
- 需要进一步的研究来证实特定的DMARDs的优越作用,并阐明它们对RA骨代谢的作用机制.
相关概念视频
Essential Minerals for Bone Health
6.4K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.4K
Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview
11.3K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.3K
Water and Mineral Acquisition
35.7K
Specialized tissues in plant roots have evolved to capture water, minerals, and some ions from the soil. Roots exhibit a variety of branching patterns that facilitate this process. The outermost root cells have specialized structures called root hairs that increase the root surface, thus increasing soil contact. Water can passively cross into roots, as the concentration of water in the soil is higher than that of the root tissue. Minerals, in contrast, are actively transported into root cells.
35.7K
Minerals
1.3K
Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
Major...
Major...
1.3K
Random and Systematic Errors
14.9K
Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
14.9K


