灰质缩和后皮层缩中的结构连接:基于voxel的元分析
Daniele Licciardo1, Chiara Matti2, Alberto Benelli3
1Neurology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy, School of Medicine and Surgery, University of Milano-Bicocca, Italy; Precision Neuromodulation Program & Network Control Laboratory, Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
后皮层缩 (PCA) 涉及渐进的视力衰退和大脑缩,特别是在尾和顶区域. 这一元分析揭示了灰色和白质的关键变化,为诊断提供了潜在的成像生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 神经学 神经学
背景情况:
- 后皮层缩 (PCA) 是一种神经退行综合征,通常与阿尔茨海默病有关,导致渐进的视觉空间和视觉感知缺陷.
- 现有的基于voxel的形态测量研究表明PCA中的灰质损失,但缺乏全面的元分析和对结构连接性改变的理解.
研究的目的:
- 在后皮层缩 (PCA) 中进行基于voxel的形态测量研究的系统审查和基于坐标的元分析.
- 通过扩散核磁共振谱学研究PCA中灰质缩相关的结构连接性改变.
- 根据共识诊断标准,提供PCA中大脑变化的统计学 robust 描述.
主要方法:
- 18项研究 (339名PCA患者,577名对照组) 的系统综述和基于voxel的元分析,使用基于种子的d映射与对象图像的变换 (SDM-PSI).
- 进行元回归分析,以探索人口和临床变量对缩模式的影响.
- 在规范扩散MRI模板上的确定性曲谱,使用元分析灰色物质集群作为种子来评估白质完整性.
主要成果:
- 在PCA患者的元分析中,发现了PCA患者侧皮质,下叶,前骨和腹角区域的显著双边灰色质缩.
- 超回归显示,年龄和疾病持续时间之间存在相互作用,影响左上旋和右脑脊髓缩.
- 轨道图显示,受影响的灰质集群是主要白质通路的一部分,包括上/下纵向囊,垂直囊囊和状囊管.
结论:
- 这项研究提供了PCA大脑变化的第一个全面的元分析后共识标准,详细介绍了灰质缩模式.
- 结构连接分析强调了PCA对关键远程白质道的影响.
- 这些发现为PCA诊断和治疗标识提供了潜在的成像生物标志物.
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