丹德罗宾通过抑制Runx1-介导的NF-κB信号通路来减轻术后认知功能障碍
Dong Ji1, Qingyu Sun2, Chengcheng Zhang3
1Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200120, China; Department of Anesthesiology, Shanghai Hongkou District Jiangwan Hospital, Shanghai, 200081, China.
Brain research bulletin
|January 30, 2026
概括
丹德罗宾是一种天然化合物,通过减少神经炎症和神经元损伤来对抗术后认知功能障碍 (POCD). 它针对Runx1/NF-κB通路,为手术患者提供一种新的神经保护策略.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 老年学是一门学科.
背景情况:
- 老年人的术后认知功能障碍 (POCD) 与通过微质激活和NF-κB信号传递与神经炎症有关.
- Runx1是NF-κB的上游调节者,但其在POCD中的作用尚不清楚.
- 来自Dendrobium物种的丹德罗宾具有已知的抗炎和神经保护性质.
研究的目的:
- 研究Runx1在POCD中的作用.
- 评估丹德罗宾在改善POCD方面的治疗潜力.
- 阐明树突蛋白对神经炎症和神经元存活的影响的潜在分子机制.
主要方法:
- 在老年小鼠中使用sevoflurane麻醉和手术诱导POCD.
- 用行为测试评估认知功能 (莫里斯水迷宫,新型物体识别).
- 分子分析包括RNA测序,西式涂抹,免疫光和体外细胞培养,以检查炎症途径,亡和突触可塑性. 通过敲击和过度表达来测试Runx1的功能.
主要成果:
- 在POCD小鼠中,登德罗宾的使用改善了记忆力,并减少了神经炎症,微质激活和神经元亡.
- 登德罗宾通过降低Runx1表达的调节来抑制NF-κB信号,被确定为上游调节器.
- 抑制Runx1增强了树突蛋白的抗炎作用,而Runx1过度表达减弱了它们.
结论:
- 登德罗宾有效地通过抑制Runx1/NF-κB通路来改善POCD,从而减少神经炎症和神经元亡.
- 在POCD的背景下,Runx1充当NF-κB信号传递的关键上游媒介.
- 针对Runx1/NF-κB轴是一个有前途的治疗策略,用于术后神经保护.
相关概念视频
02:26NF-κB-dependent Signaling Pathway
10.0K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
10.0K
03:14Notch Signaling Pathway
6.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.6K
02:33Hedgehog Signaling Pathway
10.1K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.1K
01:19Interactions Between Signaling Pathways
7.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.4K
01:41Non-Canonical Wnt Signaling Pathways
8.5K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.5K
02:54Canonical Wnt Signaling Pathway
10.6K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.6K