在左腹侧前额皮层上高频rTMS可以改善中风患者的胃肠道损伤:fNIRS-HRV研究
Lin Lv1, Zhenyan Zhang2, Jun Zhang3
1Department of Rehabilitation Medicine, Tianjin Medical University General Hospital, Tianjin, China; Department of Neurology, Inner Mongolia Baotou City Central Hospital, Baotou, China; Neuromodulation and Neural Remodeling Laboratory, Tianjin Medical University General Hospital, Tianjin, China.
Neuroscience
|January 30, 2026
概括
在获得性脑损伤患者中,通过左前额叶皮层进行重复性横磁刺激 (rTMS) 改善了胃肠功能和自主调节. 这种神经调节方法显示出恢复神经自主整合的前景.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 康复医学 康复医学 康复医学
背景情况:
- 自主功能障碍是获得性脑损伤 (ABI) 的常见并发症,通常涉及由于中枢自主网络调节受损的胃肠功能受损.
- 关联功能连接受损与自主功能障碍的确切机制以及ABI患者神经调节的疗效尚不清楚.
研究的目的:
- 研究重复性跨磁刺激 (rTMS) 针对左腹侧前额皮层 (VLPFC-L) 对急性胃肠道损伤 (AGI) 的ABI患者的自主和胃肠功能的影响.
- 探索VLPFC-L rTMS对大脑功能连接和网络效率的影响.
主要方法:
- 一项随机对照试验涉及64名ABI患者,分为对照组 (CG) 和RTMS组 (TG).
- 在两周的时间里,TG在VLPFC-L上接受了标准康复加上10HzrTMS.
- 使用心率变化 (HRV) 评估自主功能,使用功能近红外光谱 (fNIRS) 测量全脑功能连接,并使用图形理论网络指标进行分析.
主要成果:
- 与对照组相比,rTMS组在AGI得分,低频 (LF) 功率降低,LF/HF比率降低,HRV高频 (HF) 功率增加方面表现出显著改善.
- VLPFC-L rTMS导致了目标区域的功能连接增加,特别是与右额头极和前运动皮层.
- 在rTMS组中,大脑功能网络中的全球和本地网络效率得到了增强.
结论:
- 在VLPFC-L上向的rTMS可以有效地恢复神经自主整合,并改善ABI患者的胃肠功能.
- fNIRS和HRV作为有价值的补充工具来评估神经调节干预对自主电路的影响.
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