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Updated: Feb 1, 2026

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
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Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

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带有生物活性纳米体的工程IgA-Fc融合蛋白中和SARS-CoV-2变种,具有粘膜传递潜力

Rachel M Golonka1, Lauren E Intravaia2, Ala M Shaqra2

  • 1Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.

The Journal of biological chemistry
|January 30, 2026
PubMed
概括

新的拉玛衍生IgA纳米体融合蛋白显示出对包括Omicron在内的SARS-CoV-2变种的强烈中和. 鼻内注射降低了小鼠肺部的病毒载量,突出了它们作为粘膜抗病毒药物的潜力.

关键词:
抗体工程是一种抗体工程.药物开发和药物提供.在Fc-融合蛋白质中.免疫性 免疫性 免疫性免疫球蛋白A (IgA) 是一种单克隆抗体是一种单克隆抗体.再组合蛋白质的表达方式这就是SARS-CoV-2病毒.单域抗体 (sdAbAb) 是一种单域抗体.结构建模 结构建模(纳米体) 是一个纳米体.

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