相关实验视频

Updated: Feb 1, 2026

A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1
08:17

A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1

Published on: April 16, 2021

2.8K

使用抗病毒核酸类型的向性向可以微调SAMHD1dNTPase活性

Christopher Dirks1, Ann-Kathrin Schlotterbeck1, Pontus Pettersson2

  • 1SciLifeLab, Department of Oncology-Pathology, Karolinska Institutet, Sweden.

The Journal of biological chemistry
|January 30, 2026
PubMed
概括

科学家们探索了如何控制SAMHD1酶活性,这会影响化疗耐药性. 他们发现,特定的抗病毒药物可以调节这种酶,为改善癌症治疗结果提供新的途径.

关键词:
全osteric调节的调节.抗病毒剂是一种抗病毒剂.酶酸盐是一种酸盐.核酸类比的核酸类比核酸代谢的核酸代谢蛋白质药物相互作用

更多相关视频

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation08:00

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

Published on: October 4, 2024

1.1K
Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores09:43

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

14.2K

相关概念视频

Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
8.7K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

2.7K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

3.1K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
40.8K
Allosteric Regulation01:08

Allosteric Regulation

Allosteric regulation of enzymes occurs when the binding of an effector molecule to a site that is different from the active site causes a change in the enzymatic activity. This alternate site is called an allosteric site, and an enzyme can contain more than one of these sites. Allosteric regulation can either be positive or negative, resulting in an increase or decrease in enzyme activity. Most enzymes that display allosteric regulation are metabolic enzymes involved in the degradation or...
63.3K
Fineness of Cement01:15

Fineness of Cement

The fineness of cement directly influences the rate of hydration, as the hydration begins at the surface of the cement particles. In addition to hydration, the fineness of cement is vital for various properties of concrete including workability, gypsum requirement, and long-term behavior. The fineness of cement is represented in terms of the specific surface of cement which is typically measured in square meters per kilogram, with several methods available for this determination.
Direct...
516