终身体育活动缓解了童年逆境对休息状态功能连接的神经影响
Lemye Zehirlioglu1, Richard Nkrumah2, Traute Demirakca2
1Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|January 30, 2026
概括
童年不良经历 (ACE) 影响大脑连接,但较高的体力活动 (PA) 水平可能会促进神经弹性. 这项研究发现,PA调节了成年人ACE和大脑功能连接之间的关系.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 公共卫生 公共卫生
背景情况:
- 童年不良经历 (ACE) 显著影响大脑发育,特别是皮质膜回路,增加精神障碍的脆弱性.
- 弹性行为中的个人差异,如身体活动,可能会缓冲这些负面影响.
研究的目的:
- 调查终身体力活动 (LPA) 是否能够缓和成人ACE和静止状态功能连接 (rs-FC) 之间的关联.
- 为了确定特定的LPA范围,其中ACE影响大脑连接.
主要方法:
- 对75名成年人进行回顾性分析,检查自我报告的LPA.
- 使用相互作用模型 (ACE × LPA) 与杏仁体,海马体和前带皮质作为种子,用于种子到声细胞分析.
- 应用了适度分析和约翰逊-尼曼技术来确定显著的LPA范围.
主要成果:
- 在皮下-大脑,视觉关联和运动网络中发现了显著的ACE × LPA相互作用.
- 高ACE与低LPA的连接性减少有关,但高LPA的连接性增加 (交叉适度).
- 显著的ACE对连接性的影响发生在特定的LPA范围内,大约为每周150-390分钟.
结论:
- 终身体力活动 (LPA) 在情绪和感官运动网络中缓和了ACE和rs-FC之间的关系.
- 较高的体力活动水平与神经连接概况相关,表明对早期逆境的弹性.
- 身体活动是促进神经生物学适应在早期生活逆境后可修改的因素.
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