在病原体之外的先天免疫激活:在恒常性炎症中细胞修复途径和DAMP之间的交叉声
Caitlyn Myers1, Najmeh Saffarzadeh1, Maria Öberg1
1Institute of Biomedicine, Department of Microbiology and Immunology, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
Immunology letters
|January 30, 2026
概括
天生的免疫力监测细胞完整性,而不仅仅是微生物. 细胞修复通路的故障会释放损伤相关分子模式 (DAMPs),导致慢性炎症和疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 天生的免疫力传统上针对病原体.
- 细胞平衡需要强大的修复机制.
- 维修失败导致内生危险信号的释放.
研究的目的:
- 审查与损伤相关的分子模式 (DAMPs).
- 将DAMP积累与特定的细胞修复缺陷联系起来.
- 探索先天免疫和细胞修复之间的相互联系.
主要方法:
- 对DAMP和细胞修复途径的文献综述.
- 分析DAMP作为维修故障的指标.
- 概念框架将修复状态与炎症联系起来.
主要成果:
- DAMP是内源性分子,信号失败的修复.
- 特定的DAMP类与基因组稳定性,蛋白质稳定性,脂质平衡和器官质量的缺陷相关.
- 慢性炎症是由由于修复失败而导致的持续的DAMP信号引起的.
结论:
- 天生的免疫和细胞修复基本上是相关的.
- 完整的修复导致过渡性,解决炎症.
- 修复失败导致慢性炎症和疾病发病.
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