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Updated: May 11, 2026

Fabricating Complex Culture Substrates Using Robotic Microcontact Printing (R-µCP) and Sequential Nucleophilic Substitution
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Published on: October 31, 2014

通过分子剂调节14-3-3σ/C-RAF"自动"抑制综合体

Markella Konstantinidou1, Holly R Vickery1, Marloes A M Pennings2

  • 1Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California San Francisco, San Francisco, California 94143, United States.

Journal of the American Chemical Society
|January 30, 2026
PubMed
概括

新的分子粘剂稳定了MAPK通路中的一个关键蛋白质复合物,为向癌症和RASopathies提供了一种新的方法. 这些剂调节蛋白质与蛋白质之间的相互作用,此前被认为是不可抗药的.

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