乳腺切除术后的II期淋巴血管侵入性乳腺癌的放射治疗策略.
Shuang Gao1, Xueqiao Yu1, Yang Li1
1Department of Breast Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, P.R. China.
Anticancer research
|January 30, 2026
概括
乳腺切除术后的放射治疗 (PMRT) 改善了早期乳腺癌患者的局部控制和无病生存率 (DFS). 在新辅助化疗 (NAC) 后获得ypN0状态的LVI阳性患者,PMRT提供了生存益处.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 乳腺癌研究研究 乳腺癌研究
背景情况:
- 淋巴血管侵袭 (LVI) 是乳腺癌的显著预后指标,与较差的生存结果相关.
- 乳腺切除术后放射治疗 (PMRT) 对LVI早期乳腺癌患者的确切临床益处仍然是正在进行的研究领域.
- 现实世界的数据对于评估PMRT的疗效和识别不同患者群体中相关的预后因素至关重要.
研究的目的:
- 评估乳腺切除术后放射治疗 (PMRT) 在改善淋巴血管侵袭 (LVI) 乳腺癌患者的生存结果方面的疗效.
- 为了确定影响治疗反应和生存的预后因素,在这个患者队列.
- 评估辅助放射治疗对局部无复发生存率 (LRFS),无病生存率 (DFS),总生存率 (OS) 和远程DFS (DDFS) 的影响.
主要方法:
- 322名乳腺癌患者的回顾性分析,确认LVI,他们在2017年10月至2020年7月期间接受了放射治疗 (RT).
- 患者被分为两组:A组 (pT1-2N1M0) 和B组 (新辅助化疗和手术后的II阶段,ypN0).
- 卡普兰-梅尔分析用于估计生存终点,包括LRFS,DFS,OS和DDFS.
主要成果:
- 在A组中,辅助RT显著改善了5年的LRFS和DFS,与没有RT相比 (p<0.05).
- 在B组中,辅助RT显著改善了5年DFS,OS和DDFS的ypN0状态患者 (p<0.05).
- 在A组的亚组分析显示,在患有两到三个阳性淋巴结或三阴性瘤的患者中,复发风险更高.
结论:
- 辅助放射疗法在II期LVI阳性乳腺癌患者中增强了局部控制和无疾病生存率,但不是整体生存率.
- 在接受新辅助化疗后达到ypN0状态的LVI阳性患者中,PMRT显示了生存益处,支持其推.
- 需要进一步进行广泛的研究来证实这些发现,并完善LVI阳性乳腺癌的治疗策略.
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