部剖析和免疫检查点抑制剂在头部和部癌症中的有效性:一项回顾性研究
Yoh-Ichiro Iwasa1, Kentaro Hori2, Yoh Yokota2
1Department of Otorhinolaryngology-Head and Neck Surgery, Shinshu University School of Medicine, Matsumoto, Japan iwasa@shinshu-u.ac.jp.
Anticancer research
|January 30, 2026
概括
在接受免疫检查点抑制剂 (ICI) 的头癌 (HNC) 患者之前的部剖析 (ND) 与局部区域性疾病的生存率较差有关,但与远程转移无关. 这表明,ND可能会损害T细胞原始化,降低ICI的有效性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 手术瘤学手术瘤学
背景情况:
- 在瘤排水淋巴结 (TDLNs) 中的T细胞启动对于免疫检查点抑制剂 (ICI) 疗效至关重要.
- 在头癌 (HNC) 中的部剖析 (ND) 可能会去除TDLN,这可能会影响ICI的结果.
- 在HNC中,先前的ND对随后的ICI治疗的临床相关性需要研究.
研究的目的:
- 为了确定以前的ND是否会影响用nivolumab治疗的复发性或转移性HNC患者的治疗结果.
- 为了比较ICI在HNC患者的疗效,有和没有ND的病史.
主要方法:
- 对54名用nivolumab治疗的HNC患者的回顾性分析.
- 分层为局部区域性疾病 (LRD) 和远程转移 (DM) 队列.
- 在每个队列中,先前的ND和没有ND的患者之间的结果 (无进展生存率,总生存率) 的比较.
主要成果:
- 在LRD队列中,没有先前ND的患者与先前ND的患者相比,平均整体存活时间更长 (18.8个月) (9.8个月;p=0.044).
- 无进展生存率显示出类似的趋势,有利于没有先前ND的患者 (4.0个月对2.3个月;p=0.089).
- 在DM队列中的结果没有受到之前的ND的显著影响.
结论:
- 之前的ND与HNC患者的劣质生存结果有关,这些患者患有用nivolumab治疗的局部区域性疾病.
- 这些发现表明,通过损害TDLN功能,ND可能会降低ICI的疗效.
- 需要进一步的研究来探索手术干预对HNC免疫疗法反应的影响.
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