对于自闭症谱系障碍的三神经刺激的双盲模拟控制试点研究
Jae Hyun Han1, Ye Rim Kim1, Yoojeong Lee2
1Department of Psychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
概括
对于患有自闭症谱系障碍 (ASD) 的儿童来说,三神经刺激 (TNS) 是安全的,并且能很好地容忍. 这项试点研究表明,TNS可能会改善社会互惠,并减少ASD的不适应行为.
科学领域:
- 神经调节是一种神经调节.
- 神经科学是一个神经科学.
- 儿科精神病学 儿科精神病学
背景情况:
- 自闭症谱系障碍 (ASD) 在社交沟通,执行功能和感官处理方面存在挑战.
- 像三神经刺激 (TNS) 这样的非侵入性神经调节技术对精神疾病有前途,但在ASD中尚未得到充分研究.
- 在小儿ASD人群中TNS的安全性和有效性需要进一步研究.
研究的目的:
- 评估TNS在患有自闭症儿童中的安全性和耐受性.
- 探索TNS对ASD相关症状的潜在影响,包括社交沟通,注意力,执行功能,情绪调节,睡眠和感官处理.
- 检查与ASD儿童的TNS治疗相关的定量脑电图 (qEEG) 的变化.
主要方法:
- 这是一项双盲,模拟控制,随机的试验试验,涉及29名患有自闭症的7至12岁儿童.
- 参与者在4周内每晚接受28次活跃或假的TNS.
- 安全性,临床结果 (使用标准化尺度) 和qEEG频段功率在基线和第4周被评估.
主要成果:
- 发现三神经刺激 (TNS) 是安全的,耐受性良好,没有报告严重的不良事件.
- 探索性分析表明,名义上的改善有利于TNS组在不适应性行为和社会互惠方面.
- 定量脑电图 (qEEG) 显示了马的减少和α功率的增加,与增强的社会和整体功能相关联.
结论:
- 三神经刺激 (TNS) 是患有自闭症谱系障碍 (ASD) 的儿童的安全和耐受性干预措施.
- 初步发现表明,TNS可能为ASD儿童的行为和社会功能提供好处.
- 需要进行更大规模的临床试验来验证这些探索性发现,并确认TNS对ASD的疗效.
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