复杂胃分裂的围产期可获得的生物标志物:系统审查和个体患者数据元分析
Tomohiro Arai1, Wasinee Tianthong1,2, Francesca Maria Russo1
1Department of Development and Regeneration, My FetUZ Fetal Research Center, Cluster Woman and Child, Biomedical Sciences, KU Leuven, Leuven, Belgium.
Prenatal diagnosis
|January 30, 2026
概括
本综述确定了用于检测胃 (一种先天缺陷) 和预测其严重程度和并发症的关键体液生物标志物. 这些包括胎液蛋白和带血中的炎症标志物.
科学领域:
- 产周医学 产周医学
- 新生儿科学 新生儿科学
- 发现生物标志物的发现.
背景情况:
- 胃是一个先天性腹壁缺陷.
- 准确的诊断和严重程度的预测对于婴儿的最佳结果至关重要.
- 确定可靠的生物标志物对于临床管理至关重要.
研究的目的:
- 系统地审查用于胃的围产期可获得的体液生物标志物.
- 确定与疾病严重程度相关的生物标志物 (简单与复杂).
- 为了确定与产后疾病相关的生物标志物.
主要方法:
- 在多个数据库 (PubMed,Embase等) 中进行全面的文献搜索. ) 的情况.
- 包括研究报告体液生物标志物从怀孕妇女或新生儿与胃.
- 对已识别的生物标志物及其关联的数据提取和合成.
主要成果:
- 胚胎液总蛋白,IL-8和费里分化的胃胎.胎儿.
- 带血IL-8表明胃和长时间的腹腔营养.
- 新生儿尿肠脂肪酸结合蛋白反映了胃的存在和严重程度.
结论:
- 几个围产期可获得的生物标志物与胃关联.
- 特定的生物标志物与疾病严重程度和产后并发症相关.
- 这些发现支持在临床决策中潜在使用.
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