在意大利的二生双胞胎中,选择性杀胎后围产期结果的多中心评估
Mariano Lanna1, Daniela Casati1, Anna Fichera2
1Vittore Buzzi Children's Hospital, Fetal Therapy Unit "U. Nicolini", University of Milan, Milan, Italy.
Prenatal diagnosis
|January 30, 2026
概括
在二双胞胎怀孕中选择性终止在18周之前进行时是安全的. 这种手术可以降低早产的风险,改善意大利的围产期结果.
科学领域:
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 周围生理学 周围生理学
- 产科 产科 产科 产科 产科
背景情况:
- 选择性终止怀孕是二双胞胎怀孕的一个复杂的程序.
- 建立标准化的临床实践对于优化结果至关重要.
- 目前的意大利临床实践选择性终止在双双胞胎需要评估.
研究的目的:
- 评估目前的临床实践选择性终止在意大利二双胞胎怀孕.
- 为了建立国家协议,收集数据.
- 评估选择性终止程序的安全性和有效性.
主要方法:
- 对二生双胞胎怀孕 (2010-2021) 中选择性终止的回顾性多中心分析.
- 在胎儿活力之前,在超声波指导下通过腹腔内注射化进行的手术.
- 收集母亲和胎儿的特征和围产期结局,以32周前的早产为主要结局.
主要成果:
- 253名患者在平均妊娠年龄为17.6周时接受了选择性终止.
- 观察到胎儿 (6%) 和新生儿 (0.5%) 死亡率较低.
- 11.5%的分娩发生在32周之前;手术时的妊娠年龄>18周与风险增加有关 (OR2.95).
结论:
- 这是意大利第一个多中心研究,针对二妊娠中选择性终止.
- 在妊娠年龄18周之前进行该程序可能会降低早产的风险.
- 数据支持制定国家协议,用于二双胞胎怀孕的选择性终止.
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