来自MFAP2的癌症相关纤维细胞 (CAFs) 促进CRC增殖和转移,同时抑制CD8+ T细胞介导的抗瘤免疫力

Xu Zhang1, Yuxiang Fei2, Chunqi Xie3

  • 1Department of Pharmacy, Chengdu Integrated TCM & Western Medicine Hospital, Chengdu University of TCM, 18# Wanxiang East Road, Chengdu, 610041, P.R. China.

Cell death & disease
|January 30, 2026
PubMed
概括

与癌症相关的纤维细胞 (CAFs) 通过分泌MFAP5来驱动结直肠癌 (CRC) 的进展,MFAP5激活了抑制抗瘤免疫力的信号通路. 针对这种途径可能会改善CRC治疗结果.

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