奶酪消费和较低胆病风险是一个前性英国生物库研究与HDL-C调解
Wenwen Yang1,2, Zhixian Bao1,2, Yuhua Chen1,2
1The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu Province, China.
NPJ science of food
|January 30, 2026
概括
频繁的奶酪消费与胆结石 (胆结石) 的风险降低有关. 每天摄入奶酪与显著减少患上胆结石的几率有关,这可能是由高密度胆固醇水平调解的.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 胆结石 (胆结石) 是一个普遍的全球健康问题,影响10-20%的成年人.
- 饮食因素 (如奶酪消费) 与胆结石风险之间的关系尚未完全理解.
- 连接饮食与胆结石形成的生物学途径需要阐明.
研究的目的:
- 调查奶酪消费频率与患胆病的风险之间的关联.
- 探索胆固醇亚型,特别是HDL-C在这种协会中的潜在调解作用.
- 评估奶酪摄入量与胆结石发病率之间的剂量依赖关系.
主要方法:
- 一项前性队列研究,使用了来自399,467名参与者的英国生物库数据.
- 奶酪摄入量通过基线食物频率调查问卷进行评估.
- 通过医院记录,初级保健数据和自我报告识别的事件胆病.
- 统计分析包括多变量COX回归和因果调解分析.
主要成果:
- 在随访期间,共记录了15897例胆病病例.
- 较高的奶酪摄入量表明与胆病风险存在剂量依赖的逆相关性.
- 与非消费者相比,每天食用奶酪的消费者患胆结石的几率降低了26.3% (aOR=0.737).
- 高密度脂蛋白胆固醇 (HDL-C) 显著调节了这种风险降低 (4.03-6.98%调节).
结论:
- 频繁的奶酪消费与大胆病风险显著降低有关.
- 高密度脂蛋白胆固醇 (HDL-C) 在这种保护性关联中起着部分调解作用.
- 饮食奶酪摄入量可能是预防胆结石的潜在策略,需要进一步研究残留混和潜在机制.
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