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相关概念视频

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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Cognitive Development During Adolescence01:18

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During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
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The sensorimotor stage, the initial phase of Jean Piaget's theory of cognitive development, spans the first two years of a child's life. During this period, infants actively engage with their surroundings, building cognitive awareness through direct interaction with the world. This interaction is primarily based on sensory perception and motor actions, allowing infants to gradually understand basic physical properties and predict how objects interact within their environment.
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The preoperational stage, the second of Jean Piaget's four stages of cognitive development, spans approximately ages 2 to 7 and is characterized by the emergence of symbolic thinking. During this stage, children use language, images, and symbols to represent objects and concepts, enabling them to engage in imaginative and pretend play. This symbolic thinking supports children's ability to perform make-believe actions, such as imagining a broom as a horse or their hand as a phone, blending...
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The formal operational stage, as described in Piaget's cognitive development theory, begins around age 11 and extends into adulthood. It marks the emergence of advanced cognitive abilities that differentiate adolescent and adult thinking from those of younger children. This stage is characterized by abstract reasoning, hypothetical-deductive reasoning, and a more complex understanding of self and others.
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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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开发数字生物标志物,用于预测多领域干预的认知反应.

Ji Hyeun Park1, Hyun Sook Kim2, Seong Hye Choi3

  • 1Medical division, Rowan, Cheonan, South Korea.

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|January 30, 2026
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概括

一个新的数字生物标志物,反应时间精度相关性 (RTACC),在识别可能受益于认知健康多领域干预的轻度认知障碍的个体方面表现有前途.

关键词:
计算机化认知训练是计算机化的认知训练.数字生物标志物数字生物标志物轻度认知障碍 轻度认知障碍

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科学领域:

  • 认知健康中的数字生物标志物
  • 衰老的神经科学 衰老的神经科学
  • 计算精神病学是一种计算精神病学.

背景情况:

  • 计算机化认知训练产生性能指标,可用作数字生物标志物.
  • 轻度认知障碍 (MCI) 对早期发现和干预提出了挑战.
  • 多领域干预旨在改善MCI患者的认知功能和福祉.

研究的目的:

  • 研究一种新的游戏内数字生物标志物的实用性,即反应时间精度相关性 (RTACC),在患有MCI的参与者中.
  • 评估RTACC与多领域干预后认知结果和生物标志物变化的关联.
  • 确定RTACC是否可以帮助识别对干预反应良好的人.

主要方法:

  • 利用了SUPERBRAIN-MEET随机对照试验中130名患有MCI的参与者的数据.
  • 从任务级反应时间和准确性数据计算RTACC.
  • 采用线性和逻辑回归分析来检查RTACC与认知得分 (RBANS) 和来自大脑的神经营养因子 (BDNF) 水平的关系.
  • 评估了RTACC在与临床信息相结合时预测良好反应者的能力.

主要成果:

  • 在24周内,RTACC与可重复电池用于评估神经心理状态 (RBANS) 评分的改善有显著的相关性 (p=0.002).
  • 在RTACC中,与脑衍生神经营养因子 (BDNF) 水平的变化存在边际关联 (p=0.057).
  • 除了临床数据,RTACC还获得了0.73的ROC曲线下的面积,用于识别良好反应者.

结论:

  • 新型数字生物标志物RTACC显示了监测MCI患者认知变化的潜力.
  • RTACC可以作为一种有价值的工具来识别可能从多领域干预中受益的个人.
  • 进一步的研究可以探索RTACC在不同人群和干预环境中的应用.