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Updated: Feb 1, 2026

Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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Published on: March 21, 2022

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确定MKRN1作为p53-MDM2反循环的关键调节器

Tatsuya Shimada1, Takuya Noguchi2,3, Ryuto Komatsu1

  • 1Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

Cell death and differentiation
|January 30, 2026
PubMed
概括

马科林环指蛋白1 (MKRN1) 作为一种新型E3结合酶,准MDM2进行降解,在DNA损伤时激活p53. 这种MKRN1-SIRT1通路调节p53-MDM2反循环,对于瘤抑制至关重要.

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