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Updated: Feb 1, 2026

Using Sniper-Cas9 to Minimize Off-target Effects of CRISPR-Cas9 Without the Loss of On-target Activity Via Directed Evolution
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关于CRISPR-Cas9分子演化的结构可视化

Naoto Nagahata1, Kazuki Kato2, Sota Yamada1

  • 1Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.

Nature structural & molecular biology
|January 30, 2026
PubMed
概括

从IscB到Cas9的RNA导向核酶的演变涉及显著的结构变化,导致CRISPR-Cas系统中DNA裂变特异性的增强. 这种过渡解释了转子子相关系统如何适应到适应性免疫组件中.

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